Intensive care medicine
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Intensive care medicine · Jan 1998
Case ReportsSeptic shock with disseminated microfoci in multiple organs in humans.
Histological assessment of tissue damage and localisation of bacteria in autopsy materials of patients who died of septic shock. ⋯ Massive penetration of bacteria into all tissues without significant polymorphonuclear infiltration may take place in severe septic shock.
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Intensive care medicine · Jan 1998
Randomized Controlled Trial Clinical Trial Retracted PublicationVolume therapy in the critically ill: is there a difference?
There are still several concerns about the extensive and prolonged use of hydroxyethylstarch solution (HES) in critically ill patients. The effects of volume replacement with HES over 5 days on hemodynamics, laboratory data, and organ function were compared with volume therapy using human albumin (HA). ⋯ Volume therapy with 10% HES for 5 days in the ICU patient showed no disadvantages compared with an infusion regimen using 20% albumin. Volume replacement using HES may even be associated with improved hemodynamics. HES appears to be a valuable and significantly cheaper alternative to albumin--even for prolonged volume therapy in the critically ill patient.