Revista de neurologia
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Revista de neurologia · Feb 2008
Letter Case Reports[Stroke, tranexamic acid and patent foramen ovale].
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Revista de neurologia · Jan 2008
[The neuropediatrician and the pediatric neurological emergencies].
Knowledge of the spectrum and frequencies of pediatric neurological emergencies presenting to an emergency department is vital in optimizing the quality of care delivered locally. ⋯ Neurological emergencies constitute a large percentage of pediatric emergencies. Guidelines developed for neurological emergencies should target the commonest presenting problem categories.
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Transient global amnesia (TGA) is a neuropsychological syndrome in which a sudden, temporary loss of the capacity of creating new memories and a retrograde amnesia of variable intensity occur, whereas consciousness, personal identity and attention are preserved. ⋯ There are data and arguments in favour and against the hypotheses regarding etiology of TGA, but there is no current consensus on a theory which explains in a satisfactory way the nature of this kind of amnesia.
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Revista de neurologia · Dec 2007
[Ziconotide: an innovative alternative for intense chronic neuropathic pain].
Intense chronic pain is a very important health problem, as it has a high prevalence (5-10%), a multifactorial aetiology and its management is very often a very complex affair. Treatment of severe cases sometimes requires interventional approaches, such as continuous intrathecal infusion of opioids. ⋯ Ziconotide is the first specific neuronal blocker that acts on the calcium channel by blocking the N-type voltage-dependent calcium channels. It is a new non-opioid analgesic with approved indication in the treatment of intense chronic pain, in patients who require intrathecal analgesics and are refractory to other analgesic treatments. Therefore, we shall have to consider this drug as a therapeutic alternative in patients do not experience sufficient relief with the pharmacological agents and means currently available to treat them.
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Revista de neurologia · Dec 2007
Review[Brain regulation of food intake and expenditure energy: molecular action of insulin, leptin and physical exercise].
Overweight and obesity present significant public health concerns because of the link with numerous chronic health conditions. During the last ten years, since the discovery of leptin, great advances were obtained in the characterization oh the hypothalamic mechanisms involved in the control of food intake and thermogenesis. ⋯ The physical activity is an important component on long-term weight control. The exercise markedly increased phosphorylation activity of several proteins involved in leptin and insulin signal transduction in the hypothalamus. Recently our laboratory showed that physical activity increase in sensitivity to leptin- and insulin-induced anorexia after enhances interleukin-6 production. These findings provide support for the hypothesis that the appetite-suppressive actions of exercise may be mediated by the hypothalamus.