Der Internist
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Review Case Reports
[Multicentric Castleman's disease combined with polyserositis and POEMS syndrome: case report and review article].
Castleman disease (CD) is a very rare disorder characterised by hyperplasia of the lymphoid tissue. The aetiology varies considerably and includes autoimmunological, infectious, autoinflammatory and paraneoplastic diseases (e.g. MGUS with POEMS syndrome). ⋯ The sum of these changes sometimes causes very heterogeneous symptoms and thus often makes early diagnosis difficult. The prognosis of unrecognised and untreated disease is very serious and has an average 5‑year survival rate of 55-77%. The present paper describes the case of a 79-year-old patient with refractory polyserositis who was correctly diagnosed after > 8 years.
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A 40-year old woman from Eritrea was admitted due to worsening renal function of unknown origin. The basic nephrologic workup provided no further information. ⋯ Further investigations showed a recurrence of the urogenitary tuberculosis that had already been in 2015. The finding of AIN in the absence of a typical medical history should raise suspicion of infection-related forms or AIN associated with systemic diseases.
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Case Reports
[Treatment-refractory anaemia in a 35-year-old heart transplant recipient on chronic hemodialysis].
This article presents a case of pure red cell aplasia in a 35-year-old heart transplant recipient on chronic hemodialysis. Elevated parvovirus B19 immunoglobulin M blood levels were detected along with a high viral load of 80 billion IU/ml quantified by polymerase chain reaction. ⋯ Anaemia had significantly improved 4 weeks later. Parvovirus B19 infection should be excluded in organ transplant recipients with anaemia due to ineffective erythropoiesis.