Annals of neurology
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Annals of neurology · Mar 2010
A 3-year magnetic resonance imaging study of cortical lesions in relapse-onset multiple sclerosis.
We assessed the occurrence, extent, and frequency of formation of cortical lesions (CLs) in patients with relapsing-remitting (RR) and secondary progressive (SP) multiple sclerosis (MS), and their relationship with cortical atrophy and disability progression. ⋯ In relapse-onset MS, CLs accumulate over time and are associated with disability progression. The quantification of CLs might represent an additional useful paraclinical tool to monitor MS evolution.
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Annals of neurology · Mar 2010
Triptan-induced latent sensitization: a possible basis for medication overuse headache.
Identification of the neural mechanisms underlying medication overuse headache resulting from triptans. ⋯ Triptans represent the treatment of choice for moderate and severe migraine headaches. However, triptan overuse can lead to an increased frequency of migraine headache. Overuse of these medications could induce neural adaptations that result in a state of latent sensitization, which might increase sensitivity to migraine triggers. The latent sensitization could provide a mechanistic basis for the transformation of migraine to medication overuse headache.
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Annals of neurology · Mar 2010
Comment Letter Case ReportsPredicted pathogenic missense mutation of PGRN found in a normal control.