The Journal of clinical psychiatry
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A patient is described who had a personal and family history of rage attacks, mood disturbance, and epileptiform EEGs. The patient achieved a return to emotional stability with the introduction of anticonvulsant drug therapy. Symptoms relapsed and then remitted as anticonvulsants were stopped and then reinstituted.
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Objective criteria were used to separate skid row alcoholics from others in a public detoxification program. The two groups thus formed were found to have different characteristics, which could lead to more individualized and effective treatment planning in such settings.
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Randomized Controlled Trial Clinical Trial
Nomifensine vs. imipramine in depressed inpatients.
In a double-blind random assignment study, nomifensine was compared to imipramine in a population of depressed male inpatients (N = 36; ages 22-56 years). Nomifensine and imipramine in doses of 100-150 mg/day were found to be comparable over the 4-week treatment period on the Hamilton Depression Rating Scale and Clinical Global Impressions. ⋯ Although differences were not significant, more discomforting side effects--specifically, anticholinergic, nervousness/restlessness, and sedation--were seen in the imipramine than the nomifensine group. These results indicate that nomifensine compares favorably with imipramine in the treatment of depressed inpatients.
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Randomized Controlled Trial Comparative Study Clinical Trial
Alprazolam in clinically anxious patients with depressed mood.
A double-blind study compared alprazolam and placebo in 462 clinically anxious patients with accompanying depressed mood. Alprazolam was more effective than placebo as measured by the Hamilton Anxiety Rating Scale, the Self-Rating Symptom Scale, Target Symptoms, Physician's Global Impressions, and Patient's Global Impressions. Alprazolam was not significantly different from placebo in the number of patients reporting drowsiness, the most frequent side effect.