The American journal of medicine
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Letter Clinical Trial Controlled Clinical Trial
Gabapentin therapy for diabetic neuropathic pain.
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The superoxide free radical has come to occupy an amazingly central role in a wide variety of diseases. Our metabolic focus on aerobic energy metabolism in all cell types, coupled with some chemical peculiarities of the oxygen molecule itself, contribute to the phenomenon. ⋯ Rather it appears to be a carefully regulated metabolite capable of signaling and communicating important information to the cell's genetic machinery. Redox regulation of gene expression by superoxide and other related oxidants and antioxidants is beginning to unfold as a vital mechanism in health and disease.
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Editorial Comment Biography Historical Article
In defense of the stethoscope and the bedside.