Neurosurgery
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Darbepoetin alpha is a hypersialylated analogue of erythropoietin effective on activating erythropoietin receptors. This study investigated the vasodilator and neuroprotective effects of darbepoetin alpha on experimental subarachnoid hemorrhage model and compared them with erythropoietin. ⋯ Our findings, for the first time, showed that darbepoetin alpha can prevent vasospasm and provides neuroprotection following experimental subarachnoid hemorrhage. Moreover, darbepoetin alpha showed better results when compared with erythropoietin.