Neurosurgery
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Local biological drug delivery in the brain is an innovative field of medicine that developed rapidly in recent years. Our report illustrates a unique case of de novo development of a cerebral arteriovenous malformation (AVM) after implantation of genetically modified allogeneic mesenchymal stem cells in the brain. ⋯ ALK1, activin-like kinase 1AVM, arteriovenous malformationENG, endoglin; GLP-1, glucagon-like peptide-1GLP-1R, glucagon-like peptide-1 receptorMSC, mesenchymal stem cell.
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Approximately 20% of grade II and most grade III gliomas fluoresce after 5-aminolevulinic acid (5-ALA) application. Conversely, approximately 30% of nonenhancing gliomas are actually high grade. ⋯ 5-ALA, 5-aminolevulinic acidCRT, classification and regression treeF-FET PET, 18F-fluoroethyl tyrosine positron emission tomographyFLAIR, fluid-attenuated inversion recoveryGBM, glioblastoma multiformeO-MGMT, methylguanine DNA methyltransferaseROC, receiver-operating characteristicSUV, standardized uptake valueWHO, World Health OrganizationThis is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work, provided it is properly cited. The work cannot be changed in any way or used commercially.
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Intracranial hemangioblastomas are highly vascular tumors that account for 1% to 2% of all central nervous system tumors. Preoperative embolization has been proposed to limit the often significant intraoperative blood loss associated with resection and potentially make the tumor more soft/necrotic and thus more amenable to gross total resection. The safety and efficacy of preoperative embolization of intracranial hemangioblastomas, however, are not well characterized. ⋯ n-BCA, N-butyl cyanoacrylatePVA, polyvinyl alcoholVHL, von Hippel-Lindau.