Neurosurgery
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The goal of this study was to critically evaluate the predictive efficacy of various clinical factors in spinal epidural abscess influencing outcome after surgical and/or medical treatment. ⋯ We conclude that long-term outcome after treatment of spinal epidural abscess can be predicted with the use of the proposed grading scheme. Surgical drainage plus parenterally administered antibiotics remains the recommended treatment, although medical treatment alone can also be used for certain patients.
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Biography Historical Article
Department of Neurosurgery, Karolinska Institute: 60 years.
The Swedish neurosurgical school was created during the 1920s by Herbert Olivecrona, who became the first professor of neurosurgery at the Karolinska Institute. He pioneered procedures for the treatment of arteriovenous malformations and acoustic neuromas. He was among the first to make direct attacks on berry aneurysms. ⋯ More than 300 of the procedures are performed with the gamma knife, and at least one-third of the patients are foreign referrals. There is a strong emphasis on clinically oriented research and development. There are research programs for radiosurgery, management of pain, neurooncology, treatment of traumatic brain injury, and treatment of vasospasm after subarachnoid hemorrhage.
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Impact of cerebral perfusion pressure and autoregulation on intracranial dynamics: a modeling study.
The aim of this work was to study the impact of acute cerebral perfusion pressure (CPP) changes and autoregulation on cerebral hemodynamics, intracranial pressure (ICP), and estimation of the pressure-volume index (PVI) and the possible involvement of these factors in the development of secondary brain damage. ⋯ The present study emphasizes the relevant role of CPP changes, elicited by acute arterial hypotension, in intracranial dynamics. To achieve intracranial stability, CPP should be maintained above 80 to 90 mm Hg. PVI is significantly affected by the active response of cerebral vessels. Hence, it may provide misleading information on craniospinal capacity if it is considered as an autonomous index: rather, it should always be considered together with information on CPP and the status of autoregulation.
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Biography Historical Article
Library: historical perspective. Harvey Cushing (1869-1939).
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We describe the clinical application and utility of high-resolution magnetic resonance neurography (MRN) techniques to image the normal fascicular structure of peripheral nerves and its distortion by mass lesions or trauma in the lower extremity. ⋯ MRN proved useful in the preoperative evaluation and planning of surgery in patients with peripheral nerve lesions.