Neurosurgery
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The extent of resection has been reported to be associated with overall survival in gliomas. The use of 5-aminolevulinic acid (5-ALA) has been recognized to increase the extent of tumor resection. ⋯ Mutant IDH1/2-induced metabolite changes of exogenous 5-ALA were suggested to contribute to the lesser intraoperative fluorescence in gliomas with mutant IDH1/2 than in those without.
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Practice Guideline
American Society for Stereotactic and Functional Neurosurgery Position Statement on Magnetic Resonance-Guided Focused Ultrasound for the Management of Essential Tremor.
Magnetic resonance-guided focused ultrasound thalamotomy is a novel tool in the neurosurgical armamentarium for management of essential tremor (ET). Given the recent introduction of this technology, the American Society of Stereotactic and Functional Neurosurgery (ASSFN), which acts as the joint section representing the field of stereotactic and functional neurosurgery on behalf of the Congress of Neurological Surgeons and the American Association of Neurological Surgeons, provides here the expert consensus opinion on evidence-based best practices for the use and implementation of this treatment modality. ⋯ Contraindications to therapy are also detailed. Finally, the evidence and authority on which the ASSFN bases this consensus position statement is detailed.
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The issue of whether sports-related head trauma at the youth level can result in long-term sequelae that may negatively impact the participant has been widely debated. ⋯ We demonstrate that there are few head impacts over the course of an entire season at the middle school level. Guardian Caps, safe tackling techniques, and the age of participants may have contributed to the very low number of impacts recorded and the complete lack of injuries. This study only provides data demonstrating that youth football, when Guardian Caps and safe tackling techniques are enforced, does not appear to result in significant head impacts causing immediate head injuries. This study cannot comment on the safety of playing football at the collegiate or professional level.
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The benefit of selective dorsal rhizotomies (SDR) on motor function relative to the cerebral palsy (CP) natural history remains unknown. ⋯ These results support the use of SDR in carefully selected spastic CP children.
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Genetic factors play an important role in the pathogenesis of craniosynostosis (CRS). However, the molecular diagnosis of CRS in clinical practice is limited because of its heterogeneous etiology. ⋯ The present study shows the wide genomic landscape of CRS, revealing various genetic factors for CRS pathogenesis. In addition, the results demonstrate that an efficient diagnostic workup using target panel sequencing provides great clinical utility in the molecular diagnosis of CRS.