Clinical and investigative medicine. Médecine clinique et experimentale
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Ketone bodies are produced in the liver, mainly from the oxidation of fatty acids, and are exported to peripheral tissues for use as an energy source. They are particularly important for the brain, which has no other substantial non-glucose-derived energy source. The 2 main ketone bodies are 3-hydroxybutyrate (3HB) and acetoacetate (AcAc). ⋯ The absence of ketosis in a patient with hypoglycemia is abnormal and suggests the diagnosis of either hyperinsulinism or an inborn error of fat energy metabolism. An abnormal elevation of the 3HB/AcAc ratio usually implies a non-oxidized state of the hepatocyte mitochondrial matrix resulting from hypoxia-ischemia or other causes. We summarize the differential diagnosis of abnormalities of ketone body metabolism, as well as pertinent recent advances in research.
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A 5-y (1987-1992) retrospective chart review assessed the survival of patients with acute myelogenous leukemia (AML) who required intubation/ventilatory support in the intensive care unit (ICU). Thirty-two patients were identified, average age 52 +/- 19 (range 14-82) y. Seven patients had undergone bone marrow transplantation for AML 2 weeks to 4 months prior to admission. ⋯ Acute myelogenous leukemia patients had a greater mortality than 2 other intubated patient populations in our ICU admitted during the same time period, a group of 126 consecutive admissions and 53 patients with connective tissue disease. The latter 2 control groups only included patients requiring mechanical ventilation. We conclude that AML patients who require ventilatory support for acute respiratory failure rarely survive their ICU admission.
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We tested the hypothesis that small training programs (3 or fewer residents) lack the "critical mass" needed for an optimal learning experience, and thus graduates of small programs will have a lower pass rate on the Royal College of Physicians and Surgeons of Canada (RCPSC) certifying exams that graduates of large (10 or more residents) training programs. Pass rates on the RCPSC certifying exams (written and oral) were compared to the training program size for each of 6 years from 1984/85 to 1989/90 within 10 of the 43 RCPSC (sub)specialties selected by meeting predefined program size requirements. These 10 specialties met the size variation requirements needed to test the hypothesis: neurology, cardiology, emergency medicine, community medicine, neurosurgery, urology, plastic surgery, dermatology, anatomical pathology, and respiratory medicine. ⋯ The significantly lower pass rate of IMGs, compared to Canadian/USA graduates, accounted for a portion of the correlation of small program size with lower pass rates in these 3 specialties. By pooling the results from the 10 specialties evaluated, candidates from small (3 or fewer residents) training programs have slightly lower pass rates (11%) on written certification examinations compared to candidates from large (10 or more residents) training programs. This small but statistically significant effect on the pooled results was due to averaging of a more marked program size effect from 3 of the 10 specialties.(ABSTRACT TRUNCATED AT 250 WORDS)
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Randomized Controlled Trial Clinical Trial
Dehydration during fasting increases serum lipids and lipoproteins.
The study was an open, prospective, randomized cross-over design to determine if dehydration during fasting increases lipid concentrations. Fifteen healthy subjects participated, 1 of whom did not complete the study. The subjects fasted once with no fluid replacement and once with salt and water supplementation. ⋯ Fasting with fluid restriction results in significantly higher lipid levels and, therefore, variation in hydration of patients could contribute to fluctuation in lipid levels of patients. Care should be taken to ensure that patients are in a standard state of hydration during assessment of lipid levels. We recommend: 1) that patients fast no longer than 12 h, and 2) that, during fasting, patients avoid unnecessary physical activity, avoid hot dry environments, ensure a liberal intake of water, and avoid diuretic substances such as caffeine.
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Our objective was to determine the extent to which Intensive Care Unit (ICU) physicians are aware of charges for commonly used blood tests. We also wished to ascertain ICU physicians' perception of their motivation for, and appropriateness of, test ordering. Attending physicians and Internal Medicine residents in four university-affiliated ICUs in Hamilton were surveyed using a self-administered questionnaire. ⋯ Physicians perceived that they pay insufficient attention to the risk of anemia and to issue of cost. Their feeling that test ordering in the ICU is excessive suggests that they may be open to modifying their practice. Given the large proportion of hospital resources allocated to the intensive care unit, interventions to decrease test ordering are warranted.