Irish journal of medical science
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Excessive alcohol consumption is ingrained in Irish society and is known to have significant adverse health consequences, including adverse outcomes for critically ill patients. Previous assessments of alcohol-related intensive care unit (ICU) admissions were felt to have underestimated the scale of this problem. ⋯ This study adds to the data available on the scale of alcohol-related problems amongst Irish healthcare system patients. Prioritisation of primary preventative strategies is necessary.
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Anal intraepithelial neoplasia (AIN) rarely receives as much publicity as its neighbouring orifice, the cervix. As in the cervix, intraepithelial neoplasias are precursors to cancer in the anal canal. AIN and cervical interstitial neoplasia (CIN) undergo dysplasia as a consequence of human papillomavirus (HPV) infection. Since the advent of screening with the Pap smear in CIN, cervical cancer has plummeted to a fifth of its initial incidence. Anal cancer, however, has been rising, with a predilection for human immunodeficiency virus-infected men. HPV causes a squamous epithelial dysplasia and converts healthy tissue into AINs of increasing severity until anal cancer manifests. ⋯ The paper concludes by briefly discussing the implications of a national screening programme against AIN in the future.