Irish journal of medical science
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Both central and peripheral opioid receptors activation produce cardioprotection. This study investigates the role of central and peripheral opioid receptors in intravenous morphine preconditioning (MPC) and ischemic preconditioning (IPC). ⋯ MPC could mimic IPC, produce a similar cardioprotective effect. Both central and peripheral opioid receptors mediate in the cardioprotection of MPC, however, only peripheral opioid receptors in IPC.