Irish journal of medical science
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Autonomic dysfunction is commonly observed in patients with long-standing type 2 diabetes. Previous studies have confirmed the value of both subjectively assessed symptoms and objective measurements of autonomic nervous system function in diagnosing cardiovascular autonomic neuropathy. However, the head-up tilt test (HUTT) has been rarely used to investigate cardiovascular autonomic responses in subjects with high risk of newly diagnosed type 2 diabetes (nT2D). ⋯ Cardiovascular autonomic neuropathy, expressed as blunted BEI, is the only abnormal autonomic nervous test detected in nT2D, and it was independently associated with fasting glucose and HbA1c values.
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Cell division control protein 42 (CDC42) is reported to be involved in multiple inflammation processes by regulating T cell differentiation, maintaining immune cell homeostasis, and altering their function, while no relevant studies explored its clinical role in patients with rheumatoid arthritis (RA). Therefore, this study aimed to explore the correlation of CDC42 with Th1 and Th17 cells and its association with disease risk, activity, and treatment outcomes of RA. ⋯ CDC42 has the potential to serve as a biomarker to monitor disease activity and treatment efficacy in patients with RA.
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Lung cancer is the leading cause of cancer deaths in many Western countries, but its incidence has never been studied in Northern Ireland. ⋯ Northern Ireland had the lowest incidence of lung cancer in the UK, but its overall rate was still 40% higher than that observed in the Republic of Ireland which had the lowest rate in the British Isles. Across regions, the pattern of incidence by age and sex was complicated, but a linear logistic model fitted all of the Irish data and the female data in Scotland, satisfactorily.
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Symptoms related to Coronavirus-19 disease (COVID-19) and quarantine measures have caused pulmonary function abnormality and impaired respiratory mechanics. However, no studies are evaluating pulmonary functions and respiratory muscle strength in female volleyball players according to COVID-19 status in the pandemic. ⋯ Inspiratory and expiratory muscle strength in COVID-19 players were more affected compared with non-COVID-19 players. Pulmonary functions were mostly preserved in COVID-19 players. Respiratory muscle weakening can affect the performance of female players. Therefore, respiratory muscle strength training could be suggested in female players with COVID-19 to increase respiratory muscle strength and prevent deterioration in performance. TRIAL REGISTRATION (CLINICALTRIALS.GOV): Registration ID: NCT04789512.
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It is highly probable that the COVID-19 outbreak, one of the most severe pandemics to which humanity has been exposed, will promote post-traumatic stress disorder (PTSD). PTSD is a serious mental illness that decreases quality of life and functionality of healthcare workers (HCWs) during the COVID-19 pandemic. ⋯ HCWs who are working directly with COVID-19 patients have significantly higher levels of PTSD. PTSD can lead to severe negative consequences such as lower quality of life and loss of workforce and productivity, if it is not diagnosed and treated early. Therefore, it should become a routine to continuously monitor and establish early targeted mental health interventions.