Irish journal of medical science
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In ulcerative colitis patients, Elabela levels and the relation of Elabela with laboratory parameters is unknown. ⋯ Elabela concentrations in patients with active UC was significantly higher and was associated with EAI and hs-CRP. Blood Elabela concentrations can be useful in the diagnosis and follow-up of patients with active UC.
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Observational Study
Maternal obesity and depression reported at the first antenatal visit.
Maternal obesity and depression are common and both have been associated with adverse pregnancy outcomes. ⋯ We found that self-reported maternal depression in early pregnancy was independently associated with obesity. The prevalence of depression increased with the severity of obesity. Our findings highlight the need for implementation of strategies and provision of services for the prevention and treatment of both obesity and depression.
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Aerobic exercise training contributes to improvement of cardiopulmonary capacity, mobility, neurological function, and quality of life. ⋯ An 8-week ACE training led to significant improvement in aerobic capacity, physical performance, and PD-related disabilities.
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Cardiovascular disorders pose great threat to public health. As a common type of cardiovascular disease, atherosclerosis is characterized by high morbidity and mortality/recurrence rate. However, the pathogenesis of atherosclerosis is complex and not fully understood. The aim of this study was to investigate the influences of hsa_circRNA_102541 (circ_102541) on proliferation and apoptosis of HUVEC cells and to identify the underlying mechanisms. ⋯ Taken together, circRNA_102541 was upregulated in atherosclerosis, and knockdown of circRNA_102541 suppressed cell proliferation while promoted apoptosis of HUVEC cells via miR-296-5p/PLK1. This novel pathway may serve essential roles on the development of atherosclerosis, and circRNA_102541 could be a promising therapeutic candidate for the treatment of atherosclerosis.