Irish journal of medical science
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Sirtuins and FoxO1 are reported to be important in the pathophysiology of preeclampsia. This study aimed to investigate whether serum FoxO1 and SIRT2 concentrations differ between preeclampsia and normal pregnancy and also to compare these markers in early- and late-onset preeclampsia. ⋯ FoxO1 and SIRT2 may be biomarkers for early detection of preeclampsia and potential therapeutic targets in the pathophysiology of preeclampsia.
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Hypertension is a major contributor to global cardiovascular morbidity and mortality. Treatment-resistant hypertension (TRH) presents a significant management challenge, requiring a pharmacist-physician collaborative model to achieve sustained blood pressure (BP) control. ⋯ Clinical pharmacy interventions significantly enhance medication adherence and improve patient achievement of target BP goals in TRH patients. Incorporating clinical pharmacy services into routine care can lead to better health management and increased patient QoL. Further research is needed to explore long-term benefits and cost-effectiveness.
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Postoperative pain following laparoscopic cholecystectomy (LC) is a major concern. The transversus abdominis plane block (TAPB) is one of the anesthetic techniques that has been developed to address this issue. The TAPB can be delivered by the guidance of either ultrasound (UTAPB) or laparoscopic (LTAPB). Our aim is to compare the efficacy of these guidance methods in reducing postoperative pain after LC. ⋯ Ultrasound guidance of TAPB offers superior pain relief in the setting of LC, especially in the early postoperative period. Further trials are needed to prove and support the results.
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This study aimed to investigate the effect of the COVID-19 pandemic on the clinical and pathological stages of patients diagnosed with breast cancer. ⋯ In pandemic situations such as COVID-19, restrictions in social life and fear of contamination can prolong the time of admission to the hospital. This may cause delays in the diagnosis of malignant diseases such as breast cancer and progression in the disease stage. In these and similar outbreaks, public awareness should be raised, and the public should be encouraged to comply with screening and follow-up programs in order to continue outpatient clinic activities and screening programs without interruption by taking contamination measures.
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Cancer has adverse consequences for mental health, especially in women. Lack of awareness of services and stigma diminish access to psycho-oncology services. ⋯ Limited awareness of psycho-oncology services exist despite high rates of extreme distress among women with cancer.. Given that women have higher levels of extreme distress, it would be prudent to offer them enhanced psycho-oncological care.