Irish journal of medical science
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This study aimed to investigate the effect of long non-coding RNA-plasmacytoma variant translocation 1 (lnc-Pvt1) knockdown on regulating cell proliferation and apoptosis, and to explore its molecular mechanism in multiple myeloma (MM). ⋯ Lnc-Pvt1 knockdown inhibits cell proliferation and induces cell apoptosis through potentially regulating miR-486-mediated CDK4 and BCAS2 in MM.
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In Europe, adverse drug reactions and drug interactions are the cause of considerable morbidity and mortality. In over 75s, hospital access due to adverse drug reactions can be as high as 1 in every 3. ⋯ Focusing on patients with at least 4 drugs in therapy is the right strategy to reduce the risks associated with polypharmacy.
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In the original version of this article, the author list contained a number of errors, namely a missing author name, and author names that had been merged incorrectly.
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Since August 2018, Irish health research is regulated by the European General Data Protection Act (GDPR) 2016 with the (Irish) Data Protection Act and Health Research Regulations (HRR) 2018. The Irish application of GDPR has been criticised by consultants and academics as overly restrictive; however, Non-consultant Hospital Doctor's (NCHD's) perspectives have not been explored. ⋯ Our results confirm that NCHDs in Ireland are enthusiastic about engaging in research. The majority acknowledge the value of research in career development. Engaging in research abroad could be further explored as a factor impacting emigration. Our findings show that NCHDs in Ireland are concerned about the impact of GDPR and HRR and are seeking further training.
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The above article was published online with inverted given and family names of the corresponding author. Given name should be Ludmila and Danilowicz-Szymanowicz is the Family name. The correct presentation has been corrected above.