Japanese journal of clinical oncology
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Jpn. J. Clin. Oncol. · May 2012
Multicenter StudyPhase II study of intensive post-remission chemotherapy and stem cell transplantation for adult acute lymphoblastic leukemia and lymphoblastic lymphoma: Japan Clinical Oncology Group Study, JCOG9402.
To evaluate the efficacy and safety of intensive post-remission chemotherapy for untreated patients aged 15-69 years with adult acute lymphoblastic leukemia and lymphoblastic lymphoma in a multicenter Phase II study. ⋯ Although the intensified induction and post-remission chemotherapy was feasible and 28% of the patients with adult acute lymphoblastic leukemia or lymphoblastic lymphoma achieved long-term progression-free survival, JCOG9402 did not show improvement.
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Jpn. J. Clin. Oncol. · May 2012
The current status and issues regarding hospital-based specialized palliative care service in Japanese Regional Cancer Centers: a nationwide questionnaire survey.
Palliative care consultation teams have become part of all Japanese regional cancer centers. However, the current status and issues regarding specialized palliative care service in the cancer centers have yet to be clarified. Therefore, we conducted a nationwide survey of the current status of palliative care service in all Japanese regional cancer centers in 2007. ⋯ Palliative care services have rapidly been developed and implemented in Japan. However, to improve the quality of palliative care services and provide more specialized palliative care within the limits of resources, it will be necessary to review the system in the future.
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Jpn. J. Clin. Oncol. · May 2012
Extraskeletal Ewing's sarcoma family of tumors in adults: prognostic factors and clinical outcome.
The aim of this study was to evaluate prognostic factors, survival rate and the efficacy of the treatment modalities used in patients with extraskeletal Ewing's sarcoma. ⋯ Prognostic factors were similar to primary osseous Ewing's sarcomas. Adequate surgical resection, aggressive chemotherapy (vincristine, doxorubicin, cyclophosphamide and actinomycin-D alternating with ifosfamide and etoposide) and radiotherapy if indicated are the recommended therapy for patients with extraskeletal Ewing's sarcoma.
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Jpn. J. Clin. Oncol. · May 2012
Apocrine carcinoma as triple-negative breast cancer: novel definition of apocrine-type carcinoma as estrogen/progesterone receptor-negative and androgen receptor-positive invasive ductal carcinoma.
Apocrine carcinoma, a subtype of invasive ductal carcinoma of the breast, expresses androgen receptor (AR), but often lacks estrogen receptor (ER) and progesterone receptor (PgR). In the present study, the author immunohistochemically defined apocrine-type carcinoma as ER-/PgR-/AR+ invasive ductal carcinoma and analyzed the significance of apocrine-type carcinoma as triple-negative breast cancer. ⋯ Androgen receptor should be added to immunohistochemical panels, since apocrine-type invasive ductal carcinoma, resembling basal-like phenotypes, may show clinical behaviors different from the basal-like triple-negative breast cancer.