Neurological research
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Neurological research · May 2016
Correlative factors of cognitive dysfunction in PD patients: a cross-sectional study from Southwest China.
Cognitive dysfunction is common in Parkinson's disease (PD). A comprehensive understanding of cognitive dysfunction and its correlative factors in Chinese PD patients were not available. ⋯ Age, sex, education level, bradykinesia score, and presence of urinary symptoms are correlative factors of cognitive dysfunction in Chinese PD patients.
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Neurological research · May 2016
Evaluation of artificial nerve conduit and autografts in peripheral nerve repair in the rat model of sciatic nerve injury.
To investigate the therapeutic effect of artificial nerve conduit in the sciatic nerve injury and repair in the rat model. ⋯ The results suggest that artificial nerve conduit facilitated functional and morphological regeneration of the nerve. It seemed more effective than CCA but inferior to sciatic nerve autograft in repairing sciatic nerve injury in the rat model.
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Neurological research · Apr 2016
Restless leg syndrome: a risk factor of higher prevalence of anxiety and depression in Parkinson's disease patients.
Many studies have assessed the relationship of depression and anxiety with Parkinson's disease (PD), as well as examining restless leg syndrome (RLS) with depression and anxiety. Nonetheless, there has not been an extensive effort to show how the prevalence of RLS affects both depression and anxiety in PD patients. The objective of this study was to examine how the prevalence of RLS in PD patients affects the prevalence and severity of depression and anxiety and how they compare with each other. This study is the first of its kind that examines the effects of the combination of the two neurological conditions with depression and anxiety as well as comparing their prevalence and severity to each other. ⋯ The presence of RLS in PD patients may increase the occurrence of both anxiety and depression, but the severity of the symptoms is not significant in the two groups of the PD patients.
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Neurological research · Mar 2016
Acute hypercarbia increases the lower limit of cerebral blood flow autoregulation in a porcine model.
In the present study, our objective was to determine if hypercarbia would alter cerebral blood flow (CBF) autoregulation and reduce the ability of cerebrovascular reactivity monitoring to identify the lower limit of cerebrovascular autoregulation (LLA). ⋯ Hypercarbia without acidosis increases the observed LLA independent of alterations in ICP. Elevations in CO2 can impair cerebrovascular autoregulation, but if there is a sufficient increase in blood pressure above the CO2 altered LLA, then autoregulation persists.
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Neurological research · Mar 2016
Traumatic brain injury accelerates kindling epileptogenesis in rats.
Traumatic brain injury (TBI) is a well-known cause of symptomatic epilepsy. In animal models of post-traumatic epilepsy (PTE), progression of trauma to epilepsy takes several weeks to months. Although this long process is similar to clinical PTE, it is costly and laborious. We used a combination of TBI and kindling as an accelerated animal model to develop epilepsy in much shorter period compared to that occurring in PTE. ⋯ Traumatic brain injury facilitates acquisition of epilepsy in both chemical and electrical kindling models. Combination of trauma and kindling can be considered as an inexpensive and time-saving animal model in PTE studies.