Neurological research
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Neurological research · Jan 2011
Comparative StudyTrans-foraminal versus posterior lumbar interbody fusion: comparison of surgical morbidity.
Posterior lumbar interbody fusion (PLIF) and trans-foraminal lumbar interbody fusion (TLIF) are both accepted surgical approaches for spinal fusion in spondylolisthesis and degenerative disc disease. The unilateral approach of TLIF may minimize the risk of iatrogenic durotomy and nerve root injury; however, there is no definitive evidence to support either approach. We review our experience with TLIF versus PLIF to compare operative complications. ⋯ In our experience with surgical management of degenerative disc disease and spondylolesthesis, PLIF versus TLIF was associated with a trend toward a higher incidence of nerve root injury and durotomy. However, iatrogenic nerve root dysfunction was transient in all cases and 12-month pseudoarthrosis rates were similar between cohorts. Similar to previous clinical studies, the incidence of neurological complications and durotomy increases when an interbody fusion is performed through a posterior approach compared to non-interbody fusion techniques. However, the fusion rates with the interbody technique are also enhanced. TLIF and PLIF should only be considered when the goals of surgery cannot be addressed with decompression and traditional posterolateral fusion.
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Neurological research · Dec 2010
Randomized Controlled Trial Comparative StudyEffects of minimally invasive techniques for evacuation of hematoma in basal ganglia on cortical spinal tract from patients with spontaneous hemorrhage: observed by diffusion tensor imaging.
To observe the effect of minimally invasive removal of intracranial hematoma in basal ganglia on cortical spinal tract (CST). ⋯ The changes of CST could be visualized by DTI in patients with ICH. Minimally invasive removal of intracranial hematoma could effectively reduce the injury to the CST and could restore the CST which was oppressed and displaced by the hematoma to the normal position.
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Neurological research · Dec 2010
Case ReportsDecompressive hemicraniectomy improves outcome in patients with failed arterial recanalization after acute carotid artery occlusion.
Decompressive hemicraniectomy reduces morbidity and mortality in patients with large hemispheric stroke. However, its role in patients that underwent failed endovascular reperfusion remains unknown. ⋯ Decompressive hemicraniectomy can significantly improve functional outcome in patients with large carotid artery strokes that failed to recanalize following multi-modal reperfusion therapy. These results imply that decompressive hemicraniectomy should be planned in patients who undergo multi-modal reperfusion therapy for large carotid artery stroke.
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Neurological research · Nov 2010
Dopamine D₁ and D₂ receptor subtypes functional regulation in corpus striatum of unilateral rotenone lesioned Parkinson's rat model: effect of serotonin, dopamine and norepinephrine.
Parkinson's disease (PD) is due to widespread degeneration in the central and peripheral nervous systems. The hallmark pathology remains in the dopaminergic striatal insufficiency and degeneration of dopaminergic neurons in the substantia nigra. ⋯ Our results showed that serotonin and norepinephrine functionally reversed in dopamine receptors in rotenone-induced hemi-Parkinson's rat. This has clinical significance in the therapeutic management of PD.
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Neurological research · Oct 2010
Meta AnalysisEndovascular reperfusion therapy for acute ischemic stroke: a meta-analysis.
Intra-arterial thrombolysis has been advocated for treatment of acute ischemic stroke and several prognostic factors were identified in these patients. Other endovascular methods aiming to recanalize occluded vessels including balloon angioplasty, stenting and use of mechanical clot retrieving devices were devised. ⋯ MMRT includes intra-arterial infusion of thrombolytics and/or antiplatelet agents, mechanical clot disruption and retrieval and balloon angioplasty with stent placement. Recent results suggest that MMRT results in higher chances for both recanalization of the occluded artery and reperfusion of the ischemic tissue.