Neurological research
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Neurological research · Jan 2006
Comparative StudyQuantitative evaluation for secondary injury to perihematoma of hypertensive cerebral hemorrhage by functional MR and correlation analysis with ischemic factors.
To analyse quantitatively for the secondary injury to the perihematoma region of intracerebral hemorrhage (ICH) patients by functional MR imaging technique. ⋯ We have concluded that rCBV and MTT of perihematoma region decreased remarkably compared with the contralateral side, and the decline would last over 3 weeks. Quantitative research suggested edema intensity is closely related with rCBV. We believe that the reduced regional blood flow of perihematoma contributes to the secondary ischemic injury of perihematoma tissue. However, the peak of edema would appear later than the onset of the peak of ischemia, it suggests that edema surrounding the hematoma is not only the result from the single ischemic factor, but also results from multiple disadvantage mechanisms.
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Neurological research · Jan 2006
Comparative StudyStudy on the pathogenic mechanism of Broca's and Wernicke's aphasia.
To study the mechanisms of aphasia by observing cerebral blood flow and metabolism changes in language functional areas of the brain using imaging, in order to develop a language rehabilitation plan for aphasia patients. ⋯ Broca's or Wernicke's area of aphasia patients exhibits hypoperfusion and hypometabolism, indicating that they might be the mechanisms of Broca's or Wernicke's aphasia.
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Neurological research · Dec 2005
Reducing unnecessary morbidity from percutaneous thermocoagulation in the treatment of trigeminal neuralgia--part C: a starting point for a somatotopic map of the human Gasserian ganglion.
An original method and technique has been designed to reduce the significant morbidity associated with techniques currently used for percutaneous thermocoagulation in the treatment of trigeminal neuralgia. The current report deals with the mathematical and biostatistical analysis of verbal responses gathered using such a method in an attempt, as a starting point, to establish the somatotopic organization of the human gasserian ganglion. ⋯ From the strict clinical point of view, the somatotopic map of each individual is invariant and easily analysed over long time periods. Its precise knowledge is critical for inducing smaller, properly placed lesions, in order to avoid unnecessary morbidity from percutaneous thermocoagulation in the treatment of trigeminal neuralgia. The proposed sequence of the gasserian somatotopic organization will be hopefully a useful guide for those interested in trigeminal physiological organization as well as for the therapeutic exploration of gasserian trigeminal fibers.
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Neurological research · Dec 2005
Carotid endarterectomy without shunt: the role of cerebral metabolic protection.
The optimal method to protect the brain from hemodynamic ischemia during carotid endarterectomy (CEA) remains controversial. This study reports our experience with induced arterial hypertension and selective etomidate cerebral protection in a cohort of patients who underwent CEA without shunting and continuous electroencephalography (EEG) monitoring. ⋯ Carotid endarterectomy can be safely performed with EEG monitoring and selective induced arterial hypertension and etomidate cerebral protection. Our results suggest that this method may be a good alternative for shunting and its inherent risks.
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Neurological research · Oct 2005
Can Doppler time domain analysis of microembolic signals discriminate between gaseous and solid microemboli in patients with left ventricular assist device?
Microembolic signals (MES) can be detected by transcranial Doppler sonography (TCD). To identify gaseous microemboli the inhalation of oxygen is an established method in patients with prosthetic heart valves. Time domain analysis of sample volume length (SVL) and of frequency modulation showed promising results in the discrimination between solid and gaseous microemboli. We investigated whether these time domain analyses allow the discrimination of different types of microemboli in patients with the non-pulsatile DeBakey left ventricular assist device (LVAD). ⋯ The reduction of MES under oxygen delivery confirms the gaseous nature in a substantial number of circulating microemboli produced by the DeBakey LVAD. However, SVL and frequency modulation of MES did not appear to provide valuable information regarding the structural nature of the underlying microembolic material.