Journal of the American Academy of Dermatology
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J. Am. Acad. Dermatol. · May 2004
Randomized Controlled Trial Clinical TrialNarrowband UVB and cream psoralen-UVA combination therapy for plaque-type psoriasis.
Psoralen-UVA (PUVA) and narrowband UVB (311-nm) therapy are considered to be first-line phototherapies for patients with moderate to severe psoriasis. To reduce side effects as a result of systemic resorption of psoralens, topical PUVA therapies have been developed and proven to be effective in the treatment of psoriasis. ⋯ Our results indicate that a combination therapy of narrowband UVB plus cream PUVA appears to have a significantly higher efficacy compared with either monotherapy. The cumulative UV doses were significantly lower in the combination therapy. We conclude that cream PUVA can be used in addition to narrowband UVB for areas that tend to clear less quickly than the rest of the body.
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J. Am. Acad. Dermatol. · May 2004
Dacarbazine but not temozolomide induces phototoxic dermatitis in patients with malignant melanoma.
Ten patients with malignant melanoma and phototoxic reactions under dacarbazine or 5-(3,3-dimethyl-1-triazeno) imidazole-4-carboxamide (DTIC) chemotherapy were investigated. All patients available for testing showed increased ultraviolet A-sensitivity (n = 5); patch testing revealed no type IV allergies (n = 6). In 5 patients intravenous DTIC was replaced by oral temozolomide, and no phototoxicity occurred. Temozolomide may represent an alternative for patients with DTIC-induced phototoxic skin reactions.
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J. Am. Acad. Dermatol. · Feb 2004
Review Case Reports Randomized Controlled Trial Clinical TrialSubcutaneous and cerebral cysticercosis.
Cysticercosis is a human infestation, which is considered the most common cause of seizures worldwide. The subcutaneous lesions can help in the diagnosis of neurocysticercosis. ⋯ The imaging examinations showed a massive central nervous system involvement. Physicians must be aware of the importance of subcutaneous nodule examination for the diagnosis of neurocysticercosis.
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J. Am. Acad. Dermatol. · Feb 2004
Review Case ReportsFuruncular myiasis caused by Dermatobia hominis, the human botfly.
Myiasis is a common travel-associated dermatosis. Travelers to many parts of Central and South America are susceptible to infestation by Dermatobia hominis. Despite the common name of human botfly, D hominis infests a broad range of mammals and is a severe pest to economically important farm animals in endemic regions. ⋯ He had a locally painful, firm furuncular lesion with a central pore that drained serosanguineous exudates. The patient applied an occlusive ointment and recovered the larva after it emerged. In this report we discuss the life cycle of D hominis, the differential diagnosis, and therapeutic approaches.
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J. Am. Acad. Dermatol. · Feb 2004
Clinical TrialTreatment of cutaneous sarcoidosis with thalidomide.
Although systemic corticosteroids are effective against cutaneous sarcoidosis, alternative therapies are needed. ⋯ Thalidomide efficacy and tolerance in patients with cutaneous sarcoidosis merits further evaluation in a controlled trial.