Journal of the American Academy of Dermatology
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J. Am. Acad. Dermatol. · Apr 1998
Randomized Controlled Trial Multicenter Study Clinical TrialOmega-3 fatty acid-based lipid infusion in patients with chronic plaque psoriasis: results of a double-blind, randomized, placebo-controlled, multicenter trial.
Profound changes in the metabolism of eicosanoids with increased concentrations of free arachidonic acid (AA) and its proinflammatory metabolites have been observed in psoriatic lesions. Free eicosapentaenoic acid (EPA) may compete with liberated AA and result in an antiinflammatory effect. ⋯ Intravenous omega-3-fatty acid administration is effective in the treatment of chronic plaque-type psoriasis. This effect may be related to changes in inflammatory eicosanoid generation.
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J. Am. Acad. Dermatol. · Feb 1998
Review Case ReportsMycosis fungoides with focal segmental glomerular sclerosis and nephrotic syndrome.
Cutaneous T-cell lymphoma includes mycosis fungoides and the leukemic variant, Sézary syndrome. We report the first two cases of focal segmental glomerulosclerosis in patients with cutaneous T-cell lymphoma, with nephrotic range proteinuria and review the literature on renal disease coexisting with cutaneous T-cell lymphoma. We hypothesize that glomerular injury in cutaneous T-cell lymphoma may be related to interleukin-2.
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Rat-bite fever is an uncommon bacterial illness resulting from infection with Streptobacillus moniliformis that is often transmitted by the bite of a rat. The cutaneous findings in rat-bite fever are nonspecific but have been described as maculopapular or petechial. ⋯ Diagnosis was delayed because of difficulty in identifying the pathologic organism. She was successfully treated with 10 days of ceftriaxone.
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J. Am. Acad. Dermatol. · Feb 1998
Case ReportsSolar urticaria: case report and phototesting with lasers.
Solar urticaria (SU) is a rare photosensitivity disease characterized by itching, erythema, and whealing immediately after exposure to sunlight or artificial radiation. A 28-year-old female whose history was strongly suggestive of SU, but who failed to demonstrate any photosensitivity on standard light testing with a slide projector as well as UVA and UVB broadband bulbs, developed urtication when provoked with the argon-pumped dye laser at 610 nm, 650 nm, and 690 nm. Lasers may be useful tools in performing visible phototesting, especially at longer wavelengths, in patients with SU because they are powerful and efficient, whereas slide projectors have relatively little emission toward the red wavelengths and consequently may fail to evoke an urticarial response in patients, such as ours, with high-threshold, red light-induced SU.