Journal of the American Academy of Dermatology
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J. Am. Acad. Dermatol. · May 1996
Review Case ReportsTrimethoprim-sulfamethoxazole-associated acute febrile neutrophilic dermatosis: case report and review of drug-induced Sweet's syndrome.
Sweet's syndrome, or acute febrile neutrophilic dermatosis, is characterized by fever, neutrophilia, and painful erythematous cutaneous plaques that contain a dense neutrophilic dermal infiltrate. Although the disorder is usually idiopathic, patients with drug-induced Sweet's syndrome have been described. ⋯ All patients also exhibited a temporal relationship between drug administration and clinical presentation and between drug withdrawal and healing. In patients with drug-induced Sweet's syndrome, neutrophilia is often absent.
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Botulinum toxin (BT) prevents the release of acetylcholine at the neuromuscular junction and produces reversible paralysis of striated muscle. This effect was initially used for ophthalmologic indications, particularly strabismus. ⋯ As use of BT increases and its indications expand, an understanding of this therapeutic modality is timely. This article discusses the pharmacologic aspects of BT as well as the methods for administration as they relate to its cosmetic use.
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An extraabdominal desmoid tumor of the shoulder occurring in a middle-aged woman without Gardner's syndrome is described. Two punch biopsy specimens from the tumor were initially interpreted as representing scar tissue; a third incisional biopsy specimen demonstrated the characteristic features of a desmoid tumor. Because desmoid tumors are locally aggressive, early diagnosis and treatment are crucial to minimize morbidity and mortality. Typical clinical and histologic findings characteristic of an extraabdominal desmoid tumor are described, and treatment options are reviewed.
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J. Am. Acad. Dermatol. · Jan 1996
Case Reports Clinical TrialBleomycin-mediated electrochemotherapy of basal cell carcinoma.
A new technique, electroporation, enhances the antitumor effects of a variety of chemotherapeutic agents. When used in combination with conventional chemotherapy, the procedure is termed electrochemotherapy. Exposure of cancerous tissues to pulses of electricity during electrochemotherapy appears to increase cell membrane permeability and thus intracellular access to cytotoxic drugs. Electrochemotherapy has been shown to have potent antitumor activity in a variety of in vitro studies, animal tumor models, as well as in clinical trials with squamous cell carcinomas of the head and neck. ⋯ To our knowledge, this is the first study that documents the effects of bleomycin-mediated electrochemotherapy on BCC. Studies are ongoing with intralesional bleomycin during electrochemotherapy to see whether additional antitumour effects can be produced in patients with BCC by this route of administration.