Journal of the American Academy of Dermatology
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J. Am. Acad. Dermatol. · Nov 1991
Randomized Controlled Trial Clinical TrialEpilation of upper lip hirsutism with a eutectic mixture of lidocaine and prilocaine used as a topical anesthetic.
Twenty-one patients were included in a double-blind, placebo-controlled, cross-over study with a eutectic mixture of lidocaine and prilocaine (EMLA). EMLA or placebo was placed on the upper lip for 1 hour; diathermy was then performed for 10 minutes. ⋯ Eighteen of 20 patients preferred EMLA (p less than 0.0001). Local reactions were few and mild.
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J. Am. Acad. Dermatol. · Jun 1991
Case ReportsStaphylococcal sepsis in HIV antibody seropositive psoriasis patients.
The cases of three HIV-positive men with generalized psoriasis and staphylococcal sepsis are reported. In each case the skin appeared to be the source of infection. While the patients received antibiotic therapy, the psoriatic plaques resolved despite minimal or no topical treatment.
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J. Am. Acad. Dermatol. · Jun 1991
Treatment of urticaria and angioedema: low-sedating H1-type antihistamines.
H1-type antihistamines are considered the therapeutic agents of choice for treating urticaria and angioedema. The use of traditional H1 antihistamines is limited by their side effects. In recent years low-sedating H1 antihistamines with reduced sedative and anticholinergic side effects have become popular choices for the treatment of urticaria and angioedema. ⋯ Terfenadine, cetirizine, and loratadine achieve rapid peak plasma concentrations in 1 to 2 hours, whereas astemizole has a slow onset of action. In double-blind, placebo-controlled studies of chronic idiopathic urticaria, low-sedating H1 antihistamines were more effective than placebo. The choice of a particular low-sedating H1 antihistamine depends on pharmacokinetic considerations and frequency of administration.