Journal of the American Academy of Dermatology
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J. Am. Acad. Dermatol. · Apr 2014
Comparative StudyThe prevalence of metabolic syndrome in patients with hidradenitis suppurativa.
Metabolic syndrome is a multifaceted disorder strongly associated with increased risk for development of cardiovascular disease. Chronic inflammatory diseases have been associated with metabolic syndrome. Hidradenitis suppurativa is a chronic inflammatory skin disease with significant physical and emotional sequelae. ⋯ Our results indicate that patients with hidradenitis suppurativa may be at high risk for metabolic syndrome.
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J. Am. Acad. Dermatol. · Mar 2014
ReviewSafety of dermatologic medications in pregnancy and lactation: Part II. Lactation.
Dermatologists are frequently faced with questions from women who are breastfeeding about the safety of commonly prescribed topical and systemic medications during lactation. Safety data in lactation, particularly regarding medications that are unique to dermatology, are limited and can be difficult to locate. We have consolidated the available safety data in a single reference guide for clinicians. We review literature pertaining to the safety of common dermatologic therapies in lactation and offer recommendations based on the available evidence.
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J. Am. Acad. Dermatol. · Mar 2014
Comparative StudyGeneralized bullous fixed drug eruption is distinct from Stevens-Johnson syndrome/toxic epidermal necrolysis by immunohistopathological features.
Generalized bullous fixed drug eruption (GBFDE), a particular form of fixed drug eruption (FDE), is characterized by widespread blisters and erosions and can be confused with Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). ⋯ GBFDE is a distinct disease distinguishable from SJS/TEN by particular features such as granulysin, CD56, and Foxp3 expressions.
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J. Am. Acad. Dermatol. · Mar 2014
Comparative StudyBasal cell carcinoma and squamous cell carcinoma growth rates and determinants of size in community patients.
Cutaneous basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) have poorer outcomes if treated when large. ⋯ Earlier diagnosis of BCCs, perhaps through skin checks by a physician, may reduce their size and improve outcome. SCC size did not evidently increase with time.