Journal of the American Academy of Dermatology
-
J. Am. Acad. Dermatol. · Sep 2013
Randomized Controlled Trial Multicenter StudyA randomized study to evaluate the efficacy and safety of adding topical therapy to etanercept in patients with moderate to severe plaque psoriasis.
Few clinical trials have evaluated the combination of topical corticosteroids plus systemic therapies for psoriasis. ⋯ Addition of CP to etanercept yielded increased efficacy compared with etanercept alone at week 12 without an increase in treatment-related adverse events.
-
J. Am. Acad. Dermatol. · Sep 2013
Characteristics of liver injury in drug-induced systemic hypersensitivity reactions.
The liver is the most commonly involved internal organ in drug-induced systemic hypersensitivity. However, data obtained from these patients have yet to be analyzed in depth with respect to liver injury. ⋯ The results suggest that the severity, pattern, and duration of liver injury differ according to the drug-hypersensitivity phenotype. Further studies are needed to evaluate the role of systemic corticosteroids in drug-induced systemic hypersensitivity and liver injury.