Annals of emergency medicine
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Randomized Controlled Trial Clinical Trial
Dexamethasone as adjuvant therapy for severe acute pharyngitis.
To determine the efficacy of dexamethasone as adjuvant therapy to improve pain relief in patients with severe, acute exudative pharyngitis. ⋯ In patients with severe, acute exudative pharyngitis, single-injection dexamethasone adjuvant compared with placebo resulted in statistically and clinically significant improvement, as evidenced by more rapid onset and greater degree of pain relief.
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At present, fewer than 10% of cardiopulmonary resuscitation (CPR) attempts prehospital or in hospitals outside special care units result in survival without brain damage. Minimizing response times and optimizing CPR performance would improve results. A breakthrough, however, can be expected to occur only when cerebral resuscitation research has achieved consistent conscious survival after normothermic cardiac arrest (no flow) times of not only five minutes but up to ten minutes. ⋯ More than ten drug treatments evaluated have not reproducibly mitigated brain damage in such animal models. Controlled clinical trials of novel CPCR treatments reveal feasibility and side effects but, in the absence of a breakthrough effect, may not discriminate between a treatment's ability to mitigate brain damage in selected cases and the absence of any treatment effect. More intensified, coordinated, multicenter cerebral resuscitation research is justified.
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Randomized Controlled Trial Comparative Study Clinical Trial
Buffered versus plain lidocaine for digital nerve blocks.
To test whether buffered lidocaine is less painful to administer as a digital nerve block than plain lidocaine. ⋯ Because it causes less pain and is equally efficacious, buffered lidocaine is preferable to plain lidocaine for digital nerve blocks in adults.
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Adrenergic therapy is indicated during CPR to increase the coronary and cerebral perfusion pressure. Epinephrine hydrochloride at a dosage of 1.0 mg has been the most commonly used adrenergic agonist for resuscitation of adults, but there has been considerable controversy over whether higher doses should be given. ⋯ There were no consistent adverse effects associated with the use of higher-than-standard doses of epinephrine. The consensus of the Adrenergic Agonist Panel was that: 1) epinephrine by i.v. bolus should remain the drug of choice for use during resuscitation in adults; 2) data presented from the clinical trials in adults do not support an increase in the recommended dose of epinephrine; 3) because there was no evidence of significant harm from the use of high-dose epinephrine, it was felt that use of such dosages should receive a II-b recommendation pending the results of further ongoing clinical trials; 4) the standard i.v. bolus dosage of epinephrine should be simplified to 1.0 mg every three to five minutes; and 5) the endotracheal dosage of epinephrine should be at least 2 to 2.5 times larger than the peripheral i.v. dosage.
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Review
Pediatric resuscitation pharmacology. Members of the Medications in Pediatric Resuscitation Panel.
The goal of resuscitation pharmacology is to restart the heart as quickly as possible while preserving vital organ function during chest compression. Unfortunately, the application of advanced life support to pediatric cardiac arrest patients is often unsuccessful. The goal of this paper is to review the scientific rationale and educational considerations used to derive the guidelines for medication use in the pediatric patient during CPR. ⋯ This includes the use of high-dose epinephrine, calcium, bicarbonate, and other buffer agents such as Carbicarb and THAM. Animal models simulating the etiology and pathophysiology of pediatric arrest also are needed. In both clinical and animal studies, neurologic outcome and long-term survival should be assessed rather than simply the rate of restoration of spontaneous circulation.