Annals of emergency medicine
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Review Randomized Controlled Trial Clinical Trial
The use of antiarrhythmics in advanced cardiac life support.
Antiarrhythmic agents have been used to treat malignant ventricular arrhythmias in the setting of acute myocardial ischemia with proven efficacy for many years. Thus, it has been presumed that these agents would be efficacious for the treatment of cardiac arrest. Unfortunately, hard data supporting this contention are unavailable to date. ⋯ However, given the importance of magnesium and potassium levels in the genesis of malignant arrhythmias, their levels in plasma should be assessed, and abnormalities should be promptly corrected. The potential uses of antiarrhythmic agents during advanced cardiac life support span a remarkably diverse number of applications. For the purpose of this review, only the use of these agents during CPR and during the early hours of acute or suspected acute myocardial infarction will be considered.
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Adrenergic therapy is indicated during CPR to increase the coronary and cerebral perfusion pressure. Epinephrine hydrochloride at a dosage of 1.0 mg has been the most commonly used adrenergic agonist for resuscitation of adults, but there has been considerable controversy over whether higher doses should be given. ⋯ There were no consistent adverse effects associated with the use of higher-than-standard doses of epinephrine. The consensus of the Adrenergic Agonist Panel was that: 1) epinephrine by i.v. bolus should remain the drug of choice for use during resuscitation in adults; 2) data presented from the clinical trials in adults do not support an increase in the recommended dose of epinephrine; 3) because there was no evidence of significant harm from the use of high-dose epinephrine, it was felt that use of such dosages should receive a II-b recommendation pending the results of further ongoing clinical trials; 4) the standard i.v. bolus dosage of epinephrine should be simplified to 1.0 mg every three to five minutes; and 5) the endotracheal dosage of epinephrine should be at least 2 to 2.5 times larger than the peripheral i.v. dosage.
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Although endotracheal intubation is still the most definitive technique for airway management in patients with cardiac or respiratory arrest, in some emergency care systems, use of endotracheal intubation by prehospital care personnel has been restricted by policy or statute. Therefore, alternative airway devices have been developed. These alternative airway devices include the Esophageal Obturator Airway (EOA) and Esophageal Gastric Tube Airway (EGTA), the Pharyngeotracheal Lumen Airway (PTL), and the Esophageal-Tracheal Combitube (ETC). ⋯ Therefore, proper training and expert medical supervision probably have more influence on the successful use and impact of these devices than any other factors related to the devices themselves. Future training efforts would be most useful if directed at proper endotracheal intubation training and development of improved basic ventilatory skills. Nevertheless, additional controlled, direct-comparison studies of the PTL and ETC devices are recommended and should be conducted in properly supervised emergency medical services systems.
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Emphasis on a clear airway is a primary requisite for effective CPR. Airway control in the trauma victim needs special consideration of the possibility of associated cervical vertebrae and spinal cord injury; thus, modification of the patient positioning for transport is essential. Emphasis on visualization of chest movement is the most important factor in assessing adequacy of ventilation. ⋯ Methods to measure end-tidal CO2 as a valuable check for tube position is a useful adjunct but must not be relied upon. Foreign body management continues to be controversial and remains unchanged for the present; ie, the infant < 1 year of age the recommendations are back blows followed by chest thrusts. Above 1 year of age, abdominal thrusts (Heimlich maneuver) is recommended.