Annals of emergency medicine
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Concentrated aqueous solutions of hydroxocobalamin (OHCob) are given intravenously for the treatment of cyanide poisoning. Because OHCob solutions are intensely red and have peak light absorptions at 352 nm and 525 nm, we investigated whether the presence of OHCob in serum would interfere with various automated, colorimetric chemistry measurements. ⋯ The presence of OHCob in serum interferes with several chemistry methodologies, and such interference should be anticipated when this antidote is used.