Annals of emergency medicine
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[National Highway Traffic Safety Administration. Medical conditions and driver crash risk: do license restrictions affect public safety? Ann Emerg Med. August 2000;36:164-165.].
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Glyburide, a second-generation sulfonylurea hypoglycemic agent, is metabolized by the P-450 hepatic enzyme system. Ciprofloxacin, a widely used quinolone antibiotic, is a recognized P-450 enzyme inhibitor. ⋯ We present a case of hypoglycemia and an elevated serum glyburide level after 1 week of ciprofloxacin use in a patient receiving long-term glyburide therapy. Clinicians should consider this potential interaction in patients taking glyburide who require antibiotic therapy.
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[Runge JW. NHTSA Notes Commentary: Disease control and crash injury-modifying host risk factors. Ann Emerg Med. August 2000;36:165-166.].
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[American College of Emergency Physicians. School bus safety. Ann Emerg Med. August 2000;36:179.].