Zeitschrift für Gastroenterologie
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A report is given on a 24 year old nurse, who developed two episodes of fever, chills and malaise with high serum enzyme levels and histologic proof of extensive centrolobular hepatic necrosis in association with vocational halothane exposure in the operating theatre. A cause-effect relationship was suggested by the demonstration of antibodies against halothane-altered hepatocyte membrane components. ⋯ In certain predisposed individuals, halothane even in subanaesthetic concentrations is apparently able to induce liver cell damage. Only six further reports on such liver injuries in medical personnel could be found in the literature.
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In an experimental study on 376 rats the ulcer risk was analyzed after Roux-Y-gastrojejunostomy resp. jejunal interposition. The following results were obtained: 5 to 10 months postoperatively stomal ulcers were found in up to 90%. The longer the jejunal segment, i.e. the lesser the reflux, the higher was the ulcer risk. ⋯ An additional vagotomy caused a reduction but not an elimination of the ulcer risk. We conclude from our results, that there is a protective role of the postresectional intestino-gastric reflux on the gastrojejunal anastomosis. A refluxpreventive procedure is therefore heavily ulcerprone.
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In 352 patients who were hospitalized with symptoms of an acute appendicitis, Yersinia infection were determined in 18.2% of the cases by cultural and serological methods. Infections due to Y. enterocolitica (Y. e.) serovar 0:3 were approximately 6 times more frequent than those due to Y. e. serovar 0:9. ⋯ The majority of the infections were found in the age group 9-12 years. The incidence was highest in the summer months June-August.