International journal of pediatric otorhinolaryngology
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Int. J. Pediatr. Otorhinolaryngol. · Sep 2017
Changes in pediatric tracheostomy tubes exposed to home dishwashing.
Determine the effects of household dishwashing on Tracheostomy Tube safety. ⋯ A significant decrease in tube hardness and increased surface heterogeneity were found with dishwashing. The spectral analysis demonstrated increasing fragility. We believe these effects could potentially lead to decreased mechanical safety. With increased surface heterogeneity there is a greater potential for biofilm formation. At this time, dishwashing cannot be recommended as a tracheostomy tube cleaning method.
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Int. J. Pediatr. Otorhinolaryngol. · Aug 2017
A novel mutation in the MYO7A gene is associated with Usher syndrome type 1 in a Chinese family.
We aimed to investigate the genetic causes of hearing loss in a Chinese proband with autosomal recessive congenital deafness. ⋯ This study demonstrates that the novel mutation c.3847_3848insTCTG (p. N1285LfsX24) in compound heterozygosity with c.2239_2240delAG in the MYO7A gene is the main cause of USH1 in the proband. Our study expands the mutational spectrum of MYO7A and provides a foundation for further investigations elucidating the MYO7A-related mechanisms of USH1.
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Int. J. Pediatr. Otorhinolaryngol. · Aug 2017
Speech-evoked auditory brainstem responses in children with hearing loss.
The main objective of the present study was to investigate subcortical auditory processing in children with sensorineural hearing loss. ⋯ Results obtained from the speech-evoked ABRs suggest that children with a mild to moderately-severe sensorineural hearing loss have a specific pattern of subcortical auditory processing. Our results show differences for the speech-evoked ABRs in normal hearing children compared to hearing-impaired children. These results add to the body of the literature on how children with hearing loss process speech at the brainstem level.
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Int. J. Pediatr. Otorhinolaryngol. · Jul 2017
Review Case ReportsLamotrigine induced lymphadenopathy: Case report and literature review.
Lamotrigine is an anti-epileptic drug often prescribed to children and young females. Side effects include rash, dizziness and diplopia. ⋯ We will present the case of a 17-year old female with persistent lymphadenopathy due to lamotrigine. The purpose of this case report is to inform clinicians that lymphadenopathy is a possible side effect of lamotrigine and to highlight the need for further research.
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Int. J. Pediatr. Otorhinolaryngol. · Jul 2017
Mutation analysis of common GJB2, SCL26A4 and 12S rRNA genes among 380 deafness patients in northern China.
The molecular etiology of nonsyndromic deafness in Chinese population has not been investigated systematically, our study is aim to investigate the molecular etiology of nonsyndromic deafness patients from Northern China (Heilongjiang province), in order to provide genetic test and counseling to families. ⋯ Our results demonstrate that 19.2% patients with nonsyndromic deafness were caused by mutations in three common deafness genes (GJB2, SLC26A4 and 12S rRNA) in our northern China patient group. GJB2 235delC was the most prevalent mutation, same as in the most Asian populations. These data enrich the database of deafness mutations and provide the standard for clinical diagnose, treatment and genetic counseling in Northern China population.