AJNR. American journal of neuroradiology
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AJNR Am J Neuroradiol · May 2007
Clinical TrialTime-resolved MR angiography: optimal parallel imaging method.
Time-resolved (TR) MR angiography (MRA) using parallel imaging techniques is proving to have clinical utility for improving MRA spatial and temporal resolution and separating arterial from venous anatomy. The purpose of this study was to evaluate TR MRA of the intracranial vessels at different integrated parallel acquisition technique (IPAT) factors. ⋯ To obtain arterial and venous information in a clinical setting, intracranial TR MRA is best performed with an IPAT factor of 2 with at least 5 mL of contrast.
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AJNR Am J Neuroradiol · May 2007
Clinical TrialCisternography and ventriculography gadopentate dimeglumine-enhanced MR imaging in pediatric patients: preliminary report.
Complex CSF diseases may be underdiagnosed or poorly understood on conventional CT or MR imaging. Although intrathecal CT cisternography with water-soluble iodinated contrast medium has been used, very few studies have dealt with the intrathecal use of gadopentate dimeglumine (Gd-DTPA), though it appears superior to CT. We report our experience with the intrathecal use of Gd-DTPA for MR cisternography and ventriculography in pediatric patients referred for study and treatment of complex CSF-related diseases. ⋯ Our preliminary results showed no side effects and potential useful clinical applications in the evaluation of CNS diseases involving the ventricular system or the subarachnoid space in selected pediatric patients.
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AJNR Am J Neuroradiol · May 2007
Cerebral proton magnetic resonance spectroscopy in children with diabetic ketoacidosis.
Subclinical cerebral edema occurs in many, if not most, children with diabetic ketoacidosis (DKA) and may be an indicator of subtle brain injury. Brain ratios of N-acetylaspartate (NAA) to creatine (Cr), measured by proton MR spectroscopy, decrease with neuronal injury or dysfunction. We hypothesized that brain NAA/Cr ratios may be decreased in children in DKA, indicating subtle neuronal injury. ⋯ NAA/Cr ratios are decreased in children during DKA and improve after recovery. This finding suggests that during DKA neuronal function or viability or both are compromised and improve after treatment and recovery.
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AJNR Am J Neuroradiol · May 2007
Safety and feasibility of intra-arterial nicardipine for the treatment of subarachnoid hemorrhage-associated vasospasm: initial clinical experience with high-dose infusions.
Delayed cerebral ischemia from vasospasm is a major complication after aneurysmal subarachnoid hemorrhage (SAH), but complications and/or low efficacy are associated with current therapy. We report our initial experience with intra-arterial use of a calcium channel blocker, nicardipine. ⋯ In this small series, high-dose intra-arterial nicardipine infusion to treat SAH-associated vasospasm seems to be safe and effective.
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AJNR Am J Neuroradiol · Apr 2007
Serial changes in CT cerebral blood volume and flow after 4 hours of middle cerebral occlusion in an animal model of embolic cerebral ischemia.
Neuroimaging techniques have the potential to improve acute stroke treatment by selecting the appropriate patients for thrombolytic therapy. In this study, we examined changes in cerebral blood flow (CBF) and cerebral blood volume (CBV) in an animal model of middle cerebral artery occlusion and used these to identify the parameters that best differentiate between oligemic and infarct regions. ⋯ CBF and CBV values obtained from CT perfusion imaging can be used to distinguish between oligemic and infarct regions. This information could be used to assess the viability of ischemic brain tissue.