European heart journal
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European heart journal · Jan 2018
Practice Guideline2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC).
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European heart journal · Dec 2017
Randomized Controlled Trial Multicenter StudyA common missense variant of LILRB5 is associated with statin intolerance and myalgia.
A genetic variant in LILRB5 (leukocyte immunoglobulin-like receptor subfamily-B) (rs12975366: T > C: Asp247Gly) has been reported to be associated with lower creatine phosphokinase (CK) and lactate dehydrogenase (LDH) levels. Both biomarkers are released from injured muscle tissue, making this variant a potential candidate for susceptibility to muscle-related symptoms. We examined the association of this variant with statin intolerance ascertained from electronic medical records in the GoDARTS study. ⋯ This study presents a novel immunogenetic factor associated with statin intolerance, an important risk factor for cardiovascular outcomes. The results suggest that true statin-induced myalgia and non-specific myalgia are distinct, with a potential role for the immune system in their development. We identify a genetic group that is more likely to be intolerant to their statins.
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European heart journal · Dec 2017
Review Meta AnalysisMechanical aortic valve replacement in non-elderly adults: meta-analysis and microsimulation.
To support decision-making regarding prosthetic valve selection in non-elderly adults, we aim to provide a detailed overview of outcome after contemporary mechanical aortic valve replacement (AVR). ⋯ This study demonstrates that outcome after mechanical AVR in non-elderly adults is characterized by suboptimal survival and considerable lifetime risk of anticoagulation-related complications, but also reoperation. Non-elderly adult patients who are facing prosthetic valve selection are entitled to conveyance of evidence-based estimates of the risks and benefits of both mechanical and biological valve options in a shared decision-making process.
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European heart journal · Nov 2017
Observational StudyAssociation of walking pace and handgrip strength with all-cause, cardiovascular, and cancer mortality: a UK Biobank observational study.
To quantify the association of self-reported walking pace and handgrip strength with all-cause, cardiovascular, and cancer mortality. ⋯ A simple self-reported measure of slow walking pace could aid risk stratification for all-cause and cardiovascular mortality within the general population.