The Journal of hospital infection
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Laboratory surveillance of clinical isolates for Serratia spp. revealed a sudden increase from babies in the Special Care Baby Unit (SCBU). It was established that breast-milk pumps on the post-natal wards were being disinfected inadequately, resulting in contamination of milk and cross-infection within the SCBU. ⋯ Rectal carriage by the babies was common and often prolonged. The outbreak was brought under control when the method of disinfection of the pumps was changed from soaking in hypochlorite solution to washing at 80 degrees C.
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Randomized Controlled Trial Clinical Trial
Randomised trial of intraperitoneal irrigation with low molecular weight povidone-iodine solution to reduce intra-abdominal infectious complications.
A prospective randomized trial was performed comparing the efficacy of intraperitoneal irrigation with low molecular weight povidone-iodine solution ('Betadine LMW') (PVP-I LMW) in reducing the risk of intra-abdominal infectious complications. Seventy-five patients who were undergoing surgical procedures in the face of bacterial contamination were studied. Patients were intra-operatively randomized to receive intraperitoneal irrigation prior to abdominal closure with PVP-I LMW or with saline. ⋯ A broad range of serum iodine levels were observed in control patients preoperatively and at 24 h and 7 days postoperatively. Serum iodine levels in 'Betadine LMW' patients rose approximately nine-fold by 24 h postoperatively and returned to pre-operative levels by 7 days. It was concluded that PVP-I LMW solution can reduce the incidence of intra-abdominal infectious complications when used as an intraperitoneal irrigant in patients undergoing bacterially-contaminated surgical procedures.
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Comparative Study Clinical Trial Controlled Clinical Trial
Topical burn therapy comparing povidone-iodine ointment or cream plus aserbine, and povidone-iodine cream.
A trial comparing three topical agents was carried out in patients with burns. The substances investigated were 10% povidone-iodine (PVP-I) ointment mixed with a proteolytic agent, 5% PVP-I cream alone and in combination with the same proteolytic agent. Differences were observed in healing times and bacteriological cultures. ⋯ The addition of a proteolytic agent to the cream made no difference to the results. Fewer positive cultures for Staphylococcus aureus and Pseudomonas aeruginosa were obtained in the groups treated with the cream. It was concluded that 5% PVP-I cream is a safe and effective topical agent in burns.