La Revue de médecine interne
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Thymus is the site of T-cell development and is essential for the induction of self-tolerance, by deletion of autoreactive T lymphocytes (negative selection) and by generation of regulatory T cells. Defect of the selection mechanism of both types of lymphocytes lead to autoimmune diseases. ⋯ Animal models show that regulatory T cells injection or intrathymic inoculation of antigen lead to immunological tolerance in autoimmunity and transplantation. These novel strategies could be used in human.
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A review of the literature about micronutrients status of Ile-de-France inhabitants. ⋯ Identification of the groups at risk favours a better adequacy of preventive action on micronutrient deficiencies in this population. However, the efficacy of prevention is to be determined. Controlled trials of micronutrients' supplementation may be useful to value the beneficial effects of micronutrient supplementation on the incidence of cardiovascular diseases and cancer.
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Review of the literature on epidemiologic data of sarcoidosis and risk factors. ⋯ Patent sarcoidosis is revealed when concomitant environmental factors (infective agent, climate, country) and predisposition ones (race, sex familial aggregation) appear together and inducing, in each patient, a particular sarcoidosis.