La Revue de médecine interne
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Review Case Reports
[Selective serotonin reuptake inhibitors (SSRIs) antidepressants use in hot flashes in oncology].
Menopausal women or patients treated by chemotherapy or hormonotherapy for breast cancer have often disabled hot flashes. Men with prostate cancer confronted to castration can also suffer from the same problem. In both situations, many arguments go against implementation of estrogenic treatment. Albeit, many complementary therapeutics exist, they are often unsatisfying. ⋯ Through a review of literature and clinical vignette, we will specify physiopathology and prescription modalities in this new type of indication.
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Toxocariasis is a widespread zoonotic parasitosis that is frequent in France. It is due to the presence of larvae of roundworms belonging to the genus Toxocara in the human body. Clinical signs are often non-specific. The disease can be asymptomatic or can lead to death. Toxocariasis can be thought of because of clinical signs or presence of hypereosinophilia, but the diagnosis is made by specific serology. Since there is no consensus to date regarding treatment, prevention is of paramount importance. ⋯ Further studies on toxocariasis should focus on the prevalence of this disease in French population regarding the probability of infection: living in the countryside, food habits, hygiene and presence of dogs in the neighborhood. Tools of the biological diagnosis (mainly serological techniques) should be improved, but, especially, studies should focus on the evaluation of specific treatment in order to give unquestionable guidelines on this point.
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Seven days triple therapies combining a proton pump inhibitor (PPI) and 2 antimicrobial agents (clarithromycin [C], amoxicillin [A], metronidazole [M]), are recommended for the treatment of Helicobacter pylori infection. The eradication failures have increased these last years, particularly in France (about 30%). They are essentially related to the development of antimicrobial agents resistance, mainly concerning macrolides and nitro-imidazoles. ⋯ The recent knowledge of the mutations mainly responsible for H. pylori resistance to antimicrobial agents now allows the development of detection methods based on the study of bacterial DNA. These methods have been validated for clarithromycin and should favour in the near future the determination of resistance by the use of biopsy culture or directly on the gastric biopsy.