International journal of cardiology
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Multicenter Study Observational Study
Aortopathy and regurgitation in bicuspid valve patients increase the risk of aortopathy in relatives.
Bicuspid aortic valve (BAV) is the most frequent cardiac congenital valvular disease. Although the BAV risk of first degree relatives (FDR) has been assessed (7-9%), there is little information as to the heritable risk for aortopathy. ⋯ Root and ascending aortopathy in BAV probands are strong predictors of aortopathy in their TAV-FDR. AR in BAV patients has an independent effect on the risk for ascending aortopathy in TAV-FDR.
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Multicenter Study
Impact of moderate to severe mitral stenosis in patients undergoing transcatheter aortic valve replacement.
In patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR), the impact of concomitant mitral stenosis (MS) remains unknown. The aim of this study was to determine the incidence and impact of moderate to severe MS in patients undergoing TAVR. ⋯ About 7% of patients undergoing TAVR had concomitant moderate to severe MS. The presence of MS had no negative impact on early and mid-term clinical outcomes post-TAVR. These results suggest that TAVR is a valid alternative for treating patients with aortic stenosis in the presence of moderate to severe MS.
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An involvement of neutrophil extracellular traps (NETs) in the aortic stenosis (AS) pathogenesis is unknown. ⋯ The presence of NETs in stenotic valves and association with AS severity suggest novel mechanisms involved in the disease progression.
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Multicenter Study
Impaired pulmonary function and its association with clinical outcomes, exercise capacity and quality of life in children with congenital heart disease.
Impaired pulmonary function is an independent predictor of mortality in adult congenital heart disease (CHD), but has been scarcely studied in the paediatric CHD population. ⋯ These results suggest that pulmonary function should be monitored early in life, from childhood, in the CHD population.
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There are limited data on prolonged invasive mechanical ventilation (IMV) and tracheostomy use in intubated acute myocardial infarction with cardiogenic shock (AMI-CS) patients. ⋯ In this cohort of intubated AMI-CS admissions, prolonged IMV and tracheostomy showed a temporal decrease between 2000 and 2014. Prolonged IMV and tracheostomy use was associated with high resource utilization.