Cellular and molecular neurobiology
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Cell. Mol. Neurobiol. · Aug 1997
Effect of metabolic inhibitors on membrane potential and ion conductance of rat astrocytes.
1. The aim of this study was to elucidate the effect of metabolic inhibition on the membrane potential and ion conductance of rat astrocytes. The metabolic inhibitors investigated were dinitrophenol (DNP), carbonyl cyanide p-trifluoromethoxyphenyl hydrazone (FCCP), cyanide, and oligomycin. 2. ⋯ Block of tentative KATP channels with tolbutamide (1 mM) or Cl- channels with Zn2+ (1 mM) did not inhibit the depolarization caused by DNP or FCCP. 8. In conclusion, DNP and FCCP have specific effects on the plasmalemma in rat astrocytes which may be due to opening of Cl- channels. This effect was not seen with cyanide or oligomycin and should be considered as a possible complication when DNP and FCCP are used for metabolic inhibition.
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Cell. Mol. Neurobiol. · Oct 1995
Review Comparative StudyMolecular neurobiology and pharmacology of the vasopressin/oxytocin receptor family.
1. VP and OT mediate their wealth of effects via 4 receptor subtypes V1a, V1b, V2, and OT receptors. 2. We here review recent insights in the pharmacological properties, structure activity relationships, species differences in ligand specificity, expression patterns, and signal transduction of VP/OT receptor. 3. Furthermore, the existence of additional VP/OT receptor subtypes is discussed.