Cephalalgia : an international journal of headache
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Randomized Controlled Trial Multicenter Study
Comparison of frovatriptan plus dexketoprofen (25 mg or 37.5 mg) with frovatriptan alone in the treatment of migraine attacks with or without aura: a randomized study.
Drugs for migraine attacks include triptans and NSAIDs; their combination could provide greater symptom relief. ⋯ FroDex improved initial efficacy at two hours compared to Frova whilst maintaining efficacy at 48 hours in this study. Tolerability profiles were comparable. Intrinsic pharmacokinetic properties of the two single drugs contribute to this improved efficacy profile.