Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
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J. Oral Maxillofac. Surg. · Oct 2013
Comparative StudyFunctional effects of local administration of thyroid hormone combined with chitosan conduit after sciatic nerve transection in rats.
To assess the local effect of triiodothyronine (T3) on peripheral nerve regeneration in a rat model of sciatic nerve transection. ⋯ The response to local treatment showed that thyroid hormone influenced and improved the functional recovery of peripheral nerve regeneration.
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J. Oral Maxillofac. Surg. · Oct 2013
Cyclo-oxygenase-2 expression is associated with vascular endothelial growth factor C expression and lymph node metastasis in oral squamous cell carcinoma.
Cervical lymph node metastasis in oral squamous cell carcinoma (OSCC) is recognized as a poor prognostic factor, although its mechanism remains unclear. Recently, cyclo-oxygenase-2 (COX-2) level has been found to correlate highly with vascular endothelial growth factor C (VEGF-C) and lymph node metastasis, as in other solid tumors. However, there has been no report of this correlation in OSCC. Therefore, the aim of this study was to investigate whether COX-2 immunohistochemical expression in OSCC was associated with VEGF-C expression, histopathologic parameters, and lymph node metastasis. ⋯ This study showed that VEGF-C expression was upregulated by COX-2 in OSCC. High VEGF-C expression appears to promote peritumoral lymphangiogenesis. These data indicated that lymph node metastasis is promoted by COX-2 and VEGF-C in OSCC.
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J. Oral Maxillofac. Surg. · Sep 2013
Randomized Controlled Trial Comparative StudyEfficiency of bupivacaine versus lidocaine and methylprednisolone versus placebo to reduce postoperative pain and swelling after surgical removal of mandibular third molars: a randomized, double-blinded, crossover clinical trial.
To compare 4 treatment combinations to reduce postoperative pain and swelling after surgical removal of mandibular third molars. ⋯ Bupivacaine combined with methylprednisolone reduced the postoperative pain and swelling compared with the use of lidocaine and placebo, lidocaine and methylprednisolone, or bupivacaine and placebo.
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J. Oral Maxillofac. Surg. · Jul 2013
Comparative StudyAlteration of masticatory electromyographic activity and stability of orthognathic surgery in patients with skeletal class III malocclusion.
The purposes of this study were to 1) investigate longitudinal changes in electromyographic masticatory activity subsequent to orthognathic surgery (OGS) in patients with skeletal Class III malocclusion, and 2) compare masticatory muscle activity and skeletal factors in patients with stable versus relapsed mandibular positions after OGS. ⋯ A larger sagittal relapse of mandibular setback occurred in patients with greater masticatory muscle activity. Modifications in surgical design and overcorrection should be considered in patients with greater masticatory muscle activity before OGS.