Clinical rheumatology
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Clinical rheumatology · Jan 2014
Serum endothelin-1 and NT-proBNP, but not ADMA, endoglin and TIMP-1 levels, reflect impaired right ventricular function in patients with systemic sclerosis.
Heart and pulmonary involvement is a leading cause of systemic sclerosis (SSc)-related deaths. ⋯ Serum ET-1 and NT-proBNP, but not endoglin, ADMA and TIMP-1 levels correlating with the echocardiographic parameters of RV overload, can be considered as noninvasive indicators of RV dysfunction in SSc patients.