Thrombosis research
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Thrombosis research · Sep 2015
Comparative Study Observational StudyComparative effectiveness of 3- versus 4-factor prothrombin complex concentrate for emergent warfarin reversal.
Three- and 4-factor prothrombin complex concentrates (PCC) are routinely administered for emergent reversal of warfarin, but direct comparisons of clinical outcomes are lacking. The purpose of this study was to compare the safety and effectiveness of 3- and 4-PCC in patients requiring emergent warfarin reversal. ⋯ Patients who received 4-PCC, and those with INR≤1.5 regardless of type of PCC received were more likely to survive. Thromboembolic events were low in both groups and similar to previous studies.