Thrombosis research
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Thrombosis research · Jul 2009
Hypercoagulability after trauma: hemostatic changes and relationship to venous thromboembolism.
Major trauma induces a hypercoagulable state, which is frequently complicated by pathological thrombosis. However the sequential changes in coagulation markers and their relationship to clinical thrombosis have been poorly characterized. ⋯ Major trauma leads to significantly increased and persistent thrombin generation with disruption of its regulation. Coagulation markers do not appear to add independent predictive value in detecting VTE. Increasing age is the most important clinical predictor of VTE after trauma.
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Thrombosis research · Jun 2009
Thrombophilia testing in patients with venous thromboembolism. Findings from the RIETE registry.
There is scarce information on the management habits with regard to thrombophilia testing in patients with venous thromboembolism (VTE). ⋯ Twenty-eight percent of patients meeting one or more criteria for thrombophilia testing, and 10% of those with no criteria were actually tested. Thus, a substantial proportion of thrombophilia ordering is not consistent with the recommendations made by the consensus statement.
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Cerebral venous thrombosis (CVT) is a rare presentation of venous thrombosis and has been associated with many conditions. In about 20% no risk factor is identified. The aim of this study was to assess the clot formation by thromboelastography (TEG) in patients with a history of CVT compared with healthy controls. ⋯ A persistent hypercoagulable state which could have predisposed to venous thrombosis in CVT patients and in the subgroup of patients with a thrombophilic defect could not be demonstrated by TEG.
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A reliable, animal model of massive, totally occlusive, pulmonary embolism (PE) is lacking. ⋯ This model of massive, totally occlusive, pulmonary embolism mimics well fatal PE seen in the clinic, and has the potential for use in testing of new therapeutic interventions.