Thrombosis research
-
Thrombosis research · Feb 2018
ReviewCurrent evidence of oral anticoagulant reversal: A systematic review.
Approximately 4-6% of patients treated with oral anticoagulants (OAC) will suffer from major hemorrhage or be in need of urgent surgery necessitating anticoagulant reversal therapy. Several new oral anticoagulants and reversal agents have been introduced that make it difficult for physicians to stay updated on the current evidence of reversal management. This study aims to review the recent literature on oral anticoagulation reversal therapy and to present the current evidence in an easily approachable manner. ⋯ This review supports the use of PCC for VKA reversal, specifically for 4F-PCC over FFP for laboratory reversal. There are no studies on clinical efficacy of non-specific agents for DOAC reversal and the evidence for laboratory reversal is not consistent.
-
Thrombosis research · Feb 2018
Guiding curriculum development of a national research training program in thrombosis medicine: A needs assessment involving faculty and trainees.
Several barriers exist for training and retention of clinician scientists, including difficulty in navigating research-related tasks in the workplace and insufficient mentorship. ⋯ Developing a good research question, communicating research ideas and results and the practical aspects of research are important areas to focus future efforts in thrombosis research training.
-
Thrombosis research · Jan 2018
Multicenter StudyScreening itself for disseminated intravascular coagulation may reduce mortality in sepsis: A nationwide multicenter registry in Japan.
Screening of patients with sepsis for disseminated intravascular coagulation (DIC) has been recommended in several guidelines. However, DIC screening is still not widely accepted as an essential component of sepsis management, partly because of a lack of evidence that DIC screening has an effect on mortality. We investigated whether DIC screening was associated with a survival benefit in patients with sepsis. ⋯ DIC screening was associated with a reduction in mortality in patients with sepsis. This association could be even stronger by repeating DIC screening.
-
Thrombosis research · Jan 2018
Temporal trends in outpatient management of incident pulmonary embolism and associated mortality.
In clinical trial settings, outpatient management of pulmonary embolism (PE) is feasible and safe, but less is known on its use in routine care. We determined trends in outpatient management of PE and associated mortality in a large non-select patient population. ⋯ Outpatient PE management increased over 10years while remaining fairly uncommon. Nevertheless, stable mortality and readmission rates indicate this practice is safe in routine care, and add to the growing evidence in support of outpatient PE management.