Thrombosis research
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Thrombosis research · Apr 2015
The contribution of genetic and environmental factors to changes in total and γ' fibrinogen over 5 years.
Increased fibrinogen is associated with cardiovascular disease risk. It is, however, not known to what extend environmental and genetic factors and/or their interaction influence changes in total and γ' fibrinogen over time. We aimed to determine how variation within the fibrinogen gene as well as environmental factors influence the change in total and γ' fibrinogen over time, and also whether gene-environment interactions influence total and γ' fibrinogen on a cross-sectional and prospective level in Africans. ⋯ Gene-environment interactions influenced fibrinogen levels cross-sectionally and also mediated changes in levels over time.
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Thrombosis research · Apr 2015
Assessing the anticoagulant effect of dabigatran in children: an in vitro study.
Age-related changes in the hemostatic system result in variation in response to anticoagulants and coagulation assays over childhood. This study used in vitro methods to determine i) optimum coagulation assays for dabigatran in children and ii) anticoagulant effect of dabigatran across pediatric age groups. ⋯ The dTT is the most suitable assay for measuring dabigatran concentrations in children. Fibrin clot generation and lysis assay responses to dabigatran in children over all ages were consistent and comparable to those of adults.
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Thrombosis research · Mar 2015
Multicenter StudyAn international, multicenter, prospective study of a prothrombin complex concentrate, Prothromplex Total®, in anticoagulant reversal.
Prothrombin complex concentrates (PCCs) are a common treatment option for the reversal of oral anticoagulation with vitamin K antagonists (VKAs). This study assessed efficacy and safety of Prothromplex Total®. ⋯ While there is a risk of thromboembolic events following treatment with PCC products, the number of events reported here was low and could have occurred without PCC treatment. The individualized, INR-based dosing of PCC used here for VKA anticoagulant reversal produces rapid normalization of INR to ≤ 1.3 within 30 minutes.
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Thrombosis research · Mar 2015
Meta AnalysisDietary flavonoids intake and the risk of coronary heart disease: a dose-response meta-analysis of 15 prospective studies.
Epidemiological studies evaluating the association of flavonoids intake with risk of coronary heart disease (CHD) have produced inconsistent results. We conducted a meta-analysis to summarize the evidence from prospective cohort studies regarding the association between flavonoids intake and risk of CHD. ⋯ Our results from this meta-analysis suggested that elevated flavonoids intake might have a protective effect on CHD.