Emergency medicine clinics of North America
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Thyrotoxicosis and thyroid storm are disease states that result from thyroid hormone-induced hypermetabolism. The excess thyroid hormone is released from the thyroid gland as a result of excess thyroid hormone production, or by processes that disrupt the follicular structure of the gland with subsequent release of stored hormone. True hyperthyroidism results from increased synthesis and release of thyroid hormone and can be distinguished from other causes of thyrotoxicosis by the thyroid 131I uptake. ⋯ Thyroid storm may lead to irreversible cardiovascular collapse and death if proper treatment is not initiated in the Emergency Department. Specific therapy of hyperthyroidism follows several strategies, including inhibition of hormone synthesis and release, inhibition of peripheral conversion of T4 to T3, and blocking of the systemic effects of excess thyroid hormone. Treatments directed at these ends may be initiated rapidly in the emergency setting.
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Although relatively common, aberrations in divalent cation homeostasis may be overlooked in Emergency Department patients. The intracellular concentration of ionized calcium is the major regulator of cellular function. Patients may present with signs and symptoms of deranged calcium homeostasis that range from the mild and nonspecific to the truly life threatening. ⋯ Severe hypermagnesemia is rather uncommonly encountered in the Emergency Department. The magnesium ion is an effective calcium channel blocker, and patients with severe hypermagnesemia develop profound cardiovascular and neuromuscular dysfunction as a result. In pharmacologic doses, magnesium's unique calcium channel antagonism may be clinically useful, and there is growing interest in its potential use as an antiarrhythmic, anticonvulsant, and smooth muscle relaxant.
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The management of patients with penetrating abdominal trauma is outlined in Figure 1. Patients with hemodynamic instability, evisceration, significant gastrointestinal bleeding, peritoneal signs, gunshot wounds with peritoneal violation, and type 2 and 3 shotgun wounds should undergo emergency laparotomy. The initial ED management of these patients includes airway management, monitoring of cardiac rhythm and vital signs, history, physical examination, and placement of intravenous lines. ⋯ Patients with tangential gunshot wounds and possible type 2 shotgun injuries can undergo DPL. Table 8 lists the recommended thresholds for DPL. Patients with positive DPL should undergo exploration.(ABSTRACT TRUNCATED AT 400 WORDS)
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The patient in our case report presented with an acute abdomen but stable vital signs and ABCs. The differential diagnosis initially included most of the entities discussed in this chapter. The ECG ruled out an acute MI. ⋯ The CT scan confirms the presence of free air within the peritoneal cavity, and the patient is taken to surgery for an exploratory laparotomy. The final diagnosis is perforated peptic ulcer. With hindsight, the patient and wife recall a previous diagnosis of a possible ulcer in the past.
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Blunt abdominal trauma results in potentially life-threatening injuries that require organized rapid evaluation and treatment. Resuscitation of hemodynamically unstable patients should be completed in the operating room if retroperitoneal hemorrhage is not strongly suspected. ⋯ Repeated frequent physical examinations and serial laboratory tests are essential to exclude a missed injury. Deterioration of hemodynamic status or abdominal examination are indications for urgent laparotomy regardless of the initial diagnostic impressions.