Journal of the American College of Cardiology
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J. Am. Coll. Cardiol. · Jun 1998
Unstable angina: good long-term outcome after a complicated early course.
This study was performed to investigate the long-term outcome of patients with unstable angina within subgroups of the Braunwald classification. ⋯ To our knowledge, this study is the first to demonstrate that despite a complicated course during the first year, current management results in good long-term outcome in patients with unstable angina.
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J. Am. Coll. Cardiol. · Jun 1998
Cyclooxygenase inhibition aggravates ischemia-reperfusion injury in the perfused guinea pig heart: involvement of isoprostanes.
Postischemic contractile dysfunction in the heart may be due, in part, to isoprostanes, thought to accumulate during myocardial reperfusion. This study tested whether cyclooxygenase (COX) inhibitors increase the amount of isoprostanes and, consequently, lead to deterioration of postischemic heart function. ⋯ These data demonstrate that in the guinea pig heart, COX-inhibiting drugs exacerbate loss of cardiac function after ischemia. The enhanced production of isoprostanes favors coronary vasoconstriction and leads to myocardial oxygen deprivation.
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J. Am. Coll. Cardiol. · Jun 1998
Hypothermic, closed circuit pericardioperfusion: a potential cardioprotective technique in acute regional ischemia.
This study sought to determine whether infarct size can be reduced by hypothermic pericardioperfusion. ⋯ A significant reduction in myocardial temperature, without the development of cardiac tamponade, can be attained using a pericardial catheter to cool the pericardial space. This reduction in temperature causes a significant reduction in necrotic damage. This technique might be used to cool and protect the heart as an adjunct to thrombolysis or during minimally invasive cardiac surgery.