Journal of the American College of Cardiology
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J. Am. Coll. Cardiol. · Sep 2003
Is aortic dilatation an atherosclerosis-related process? Clinical, laboratory, and transesophageal echocardiographic correlates of thoracic aortic dimensions in the population with implications for thoracic aortic aneurysm formation.
The study determined, in a population-based setting, whether dilatation of the thoracic aorta is an atherosclerosis-related process. ⋯ Age, gender, and BSA are major determinants of thoracic aortic dimensions. Atherosclerosis risk factors and aortic atherosclerotic plaques are weakly associated with distal aortic dilatation, suggesting that atherosclerosis plays a minor role in aortic dilatation in the population.
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J. Am. Coll. Cardiol. · Sep 2003
Symptom-onset-to-balloon time and mortality in patients with acute myocardial infarction treated by primary angioplasty.
The aim of the study was to evaluate the relationship between symptom-onset-to-balloon time and one-year mortality in patients with ST-segment elevation myocardial infarction (STEMI) treated by primary angioplasty. ⋯ This study shows that, in patients with STEMI treated by primary angioplasty, symptom-onset-to-balloon time, but not door-to-balloon time, is related to mortality, particularly in non-low-risk patients and in the absence of preprocedural anterograde flow. Furthermore, a symptom-onset-to-balloon time >4 h was identified as independent predictor of one-year mortality.
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J. Am. Coll. Cardiol. · Sep 2003
Randomized Controlled Trial Multicenter Study Clinical TrialA randomized trial of aspirin on the risk of embolic events in patients with infective endocarditis.
This study examined the effect of aspirin on the risk of embolic events in infective endocarditis (IE). ⋯ In endocarditis patients already receiving antibiotic treatment, the addition of aspirin does not appear to reduce the risk of embolic events and is likely associated with an increased risk of bleeding. Aspirin is not indicated in the early management of patients with IE.
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J. Am. Coll. Cardiol. · Sep 2003
Randomized Controlled Trial Clinical TrialGlucose-insulin-potassium infusion inpatients treated with primary angioplasty for acute myocardial infarction: the glucose-insulin-potassium study: a randomized trial.
In this study we considered the question of whether adjunction of glucose-insulin-potassium (GIK) infusion to primary coronary transluminal angioplasty (PTCA) is effective in patients with an acute myocardial infarction (MI). ⋯ Glucose-insulin-potassium infusion as adjunctive therapy to PTCA in acute MI did not result in a significant mortality reduction in all patients. In the subgroup of 856 patients without signs of HF, a significant reduction was seen. The effect of GIK infusion in patients with signs of HF (Killip class > or =2) at admission is uncertain.
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J. Am. Coll. Cardiol. · Sep 2003
Patterns of recurrence of congenital heart disease: an analysis of 6,640 consecutive pregnancies evaluated by detailed fetal echocardiography.
We sought to investigate the pattern of recurrence of congenital heart disease (CHD) where there is one or more affected first-degree relative. ⋯ The concordance rates of different types of CHD vary widely. Accurate diagnosis of the index case is essential for reliable counseling on patterns of recurrence. Minor CHD in the index case does not exclude more severe disease in recurrences. There appears to be significant under-referral for fetal echocardiography in paternal CHD.